|
KMID : 1102020210510010020
|
|
Applied Microscopy
2021 Volume.51 No. 1 p.20 ~ p.20
|
|
|
Ultrastructural changes in cristae of lymphoblasts in acute lymphoblastic leukemia parallel alterations in biogenesis markers
|
|
Singh Ritika
Jain Ayushi
Palanichamy Jayanth Kumar
Nag T. C.
Bakhshi Sameer
Singh Archna
|
|
|
Abstract
|
|
|
|
We explored the link between mitochondrial biogenesis and mitochondrial morphology using transmission electron microscopy (TEM) in lymphoblasts of pediatric acute lymphoblastic leukemia (ALL) patients and compared these characteristics between tumors and control samples. Gene expression of mitochondrial biogenesis markers was analysed in 23 ALL patients and 18 controls and TEM for morphology analysis was done in 15 ALL patients and 9 healthy controls. The area occupied by mitochondria per cell and the cristae cross-sectional area was observed to be significantly higher in patients than in controls (p-value?=?0.0468 and p-value
|
|
|
KEYWORD
|
|
|
Acute lymphoblastic leukemia, Electron microscopy, Mitochondrial morphology, Cristae, Mitochondrial biogenesis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
|